Szt1
Spontaneous Allele Detail

Summary

• Symbol: Szt1
• Name: seizure threshold 1
• MGI ID: MGI:2656387
• Gene: Szt1 Location: unknown Genetic Position: Chr2, Syntenic

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Spontaneous
• Mutation: Intergenic deletion
• Szt1 involves 5 genes/genome features (Arfgap1, 9230112E08Rik, Col20a1 ...) View all
• Mutation details: The Szt1 mutation represents a genomic deletion of about 300 kb of mouse chromosome 2. The deletion involves 3 known genes including those encoding the potassium channel, Kcnq2, and the nicotinic acetylcholine receptor subunit, Chrna4, and ADP-ribosylation factor GTPase activating protein 1, Arfgap1. (J:82964)
• Inheritance: Dominant

Disease models

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Szt1 Mutation: 1 strain or line available

References

• Original: J:82964 Yang Y, et al., Spontaneous deletion of epilepsy gene orthologs in a mutant mouse with a low electroconvulsive threshold. Hum Mol Genet. 2003 May 1;12(9):975-84
• All: 4 reference(s)