Il9^tm1Anjm
Targeted Allele Detail

Summary

• Symbol: Il9^tm1Anjm
• Name: interleukin 9; targeted mutation 1, Andrew NJ McKenzie
• MGI ID: MGI:2656470
• Synonyms: il9^-, IL-9^-
• Gene: Il9 Location: Chr13:56627090-56630059 bp, - strand Genetic Position: Chr13, 30.06 cM
• Alliance: Il9^tm1Anjm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82881
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was disrupted by homologous recombination of a targeting vector containing stop codons in all three reading frames and a neomycin selection cassette that replaces amino acids 54 through 59. Transcript was undetected by RT-PCR analysis of activated lymphocytes obtained from homozygous mutant mice. ELISA indicated the absence of protein in splenocyte cultures derived from homozygotes. (J:82881)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Il9 Mutation: 22 strains or lines available

References

• Original: J:82881 Townsend JM, et al., IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development. Immunity. 2000 Oct;13(4):573-83
• All: 25 reference(s)