Myh11^tm1Bdr
Targeted Allele Detail

Summary

• Symbol: Myh11^tm1Bdr
• Name: myosin, heavy polypeptide 11, smooth muscle; targeted mutation 1, Michael Bader
• MGI ID: MGI:2656492
• Synonyms: SM-MHC -
• Gene: Myh11 Location: Chr16:14012392-14109227 bp, - strand Genetic Position: Chr16, 9.71 cM
• Alliance: Myh11^tm1Bdr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82859
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 5b was replaced with a neomycin selection cassette inserted by homologous recombination. Neither transcript nor protein were detected in homozygous mutant mice by Northern or Western blot analyses. Expression of non-muscle myosin heavy chain is not affected. (J:82859)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myh11 Mutation: 94 strains or lines available

References

• Original: J:82859 Morano I, et al., Smooth-muscle contraction without smooth-muscle myosin. Nat Cell Biol. 2000 Jun;2(6):371-5
• All: 3 reference(s)