Edil3^{Tg(Sox2-cre)1Amc}
Transgenic Allele Detail

Summary

• Symbol: Edil3^{Tg(Sox2-cre)1Amc}
• Name: EGF-like repeats and discoidin I-like domains 3; transgene insertion 1, Andrew P McMahon
• MGI ID: MGI:2656539
• Synonyms: Sox2-cre, Sox2::Cre, Sox2Cre, Sox2-Cre^tg, Tg(Sox2-cre)1Amc
• Gene: Edil3 Location: Chr13:88969591-89471342 bp, + strand Genetic Position: Chr13, 45.3 cM, cytoband C3
• Alliance: Edil3^{Tg(Sox2-cre)1Amc} page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Null/knockout, Recombinase)
• Mutation: Insertion
• Edil3^{Tg(Sox2-cre)1Amc} expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Sox2 (MGI:98364)

• Mutation details: This transgene expresses Cre recombinase under the control of a mouse Sox2 promoter contained in 12.5 kb of upstream DNA. Expression of this transgene is sex-dependent, with increased efficiency when passed through the female germline. When the transgene is passed through the male germline, cre activity is observed in epiblast cells as early as E6.5 of only those embryos that inherit the transgene and no expression is detected in extraembryonic tissue. When the transgene is passed through the female germline, cre activity is observed throughout the embryo (including the yolk sac) in all early embryos regardless of whether or not they inherit the transgene. Line 1 inserted into an intron of the gene at 89311726-89311727 (Build GRCm38/mm10) resulting in a functional knockout of the gene. Founder line 1 has a copy number of 2-5. (J:83040, J:86588, J:124941, J:134483, J:178271)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sox2 (mouse) Summary of all recombinase alleles driven by Sox2. Comparative matrix view of recombinase activities Alliance mouse Sox2 gene page

Disease models

Expression

In Mice Carrying this Mutation:

452 assay results 19 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Edil3 Mutation: 43 strains or lines available

Notes

Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.

References

• Original: J:83040 Hayashi S, et al., Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech Dev. 2002 Dec;119 Suppl 1:S97-S101
• All: 528 reference(s)