Cia14^DBA/1J
QTL Variant Detail

Summary

• QTL variant: Cia14^DBA/1J
• Name: collagen induced arthritis QTL 14; DBA/1J
• MGI ID: MGI:2656566
• QTL: Cia14 Location: Chr5:113320385-138555455 bp Genetic Position: Chr5, Syntenic

Variant origin

• Strain of Specimen: DBA/1J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:82018

135 SSLP markers were screened in a set of 939 (BALB/cCrl x DBA/1J)F2 intercross animals to identify QTLs associated with collagen-induced arthritis (CIA) and proteoglycan-induced arthritis (PGIA). Parental strain BALB/cCrl is CIA-resistant and PGIA-susceptible while parental strain DBA/1J is CIA-susceptible and PGIA-resistant. A major locus was identified on mouse Chromosome 17 in linkage to both CIA (LOD=21) and PGIA (LOD=6). This locus, Pgia17, has been previously identified and maps to proximal Chromosome 17.

Pgia18, novel locus associated with PGIA, mapped to an interval spanning 0 cM - 9 cM on mouse Chromosome 5 flanked by the centromere and marker D5Mit227.. Pgia18 is linked to arthritis score (LOD=4.0), arthritis onset (LOD=3.6) and susceptibility (LOD=2.7).

Two novel loci associated with CIA mapped to mouse Chromosome 5.

Cia13 (mCia10) mapped to an interval spanning 26cM - 41cM, flanked by markers D5Mit105 and D5Mit304. Cia13 is linked to arthritis severity (LOD=4.1), susceptibility (LOD=3.0) and total arthritis score (5.0).

Cia14 (mCia11) mapped to an interval spanning 61cM - 78cM, flanked by markers D5Mit278 and D5Mit31. Cia14 is linked to arthritis severity (LOD=6.1), onset (LOD=4.2), susceptibility (LOD=4.0) and total arthritis score (LOD=7.8).

References

• Original: J:82018 Adarichev VA, et al., Combined autoimmune models of arthritis reveal shared and independent qualitative (binary) and quantitative trait loci. J Immunol. 2003 Mar 1;170(5):2283-92
• All: 1 reference(s)