Pgia19^DBA/1J
QTL Variant Detail

Summary

• QTL variant: Pgia19^DBA/1J
• Name: proteoglycan induced arthritis 19; DBA/1J
• MGI ID: MGI:2656597
• QTL: Pgia19 Location: Chr6:45290993-87403016 bp Genetic Position: Chr6, Syntenic

Variant origin

• Strain of Specimen: DBA/1J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:82018

135 SSLP markers were screened in a set of 939 (BALB/cCrl x DBA/1J)F2 intercross animals to identify QTLs associated with collagen-induced arthritis (CIA) and proteoglycan-induced arthritis (PGIA). Parental strain BALB/cCrl is CIA-resistant and PGIA-susceptible while parental strain DBA/1J is CIA-susceptible and PGIA-resistant.

A major locus was identified on mouse Chromosome 17 in linkage to both CIA (LOD=21) and PGIA (LOD=6). This locus, Pgia17, has been previously identified and maps to proximal Chromosome 17.

Pgia19, a novel locus associated with PGIA, maps to mouse Chromosome 6 to an interval spanning 19cM - 37cM, flanked by markers D6Mit223 and D6Mit9. Pgia19 is linked to soluble CD44 production (LOD=4.5), arthritis score (LOD=2.9), onset (LOD=3.1) and susceptibility (LOD=3.4).

References

• Original: J:82018 Adarichev VA, et al., Combined autoimmune models of arthritis reveal shared and independent qualitative (binary) and quantitative trait loci. J Immunol. 2003 Mar 1;170(5):2283-92
• All: 1 reference(s)