Pgia22^DBA/1J
QTL Variant Detail

Summary

• QTL variant: Pgia22^DBA/1J
• Name: proteoglycan induced arthritis 22; DBA/1J
• MGI ID: MGI:2656606
• QTL: Pgia22 Location: Chr8:102486208-116025457 bp Genetic Position: Chr8, Syntenic

Variant origin

• Strain of Specimen: DBA/1J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:82018

135 SSLP markers were screened in a set of 939 (BALB/cCrl x DBA/1J)F2 intercross animals to identify QTLs associated with collagen-induced arthritis (CIA) and proteoglycan-induced arthritis (PGIA). Parental strain BALB/cCrl is CIA-resistant and PGIA-susceptible while parental strain DBA/1J is CIA-susceptible and PGIA-resistant.

A major locus was identified on mouse Chromosome 17 in linkage to both CIA (LOD=21) and PGIA (LOD=6). This locus, Pgia17, has been previously identified and maps to proximal Chromosome 17.

Pgia22, a novel locus associated with PGIA, mapped to an interval spanning 47cM - 59cM on mouse Chromosome 8 flanked by markers D8Mit242 and D8Mit320. Pgia22 is linked to IL-1 production (LOD=3.1)

A novel locus associated with CIA, Cia16, maps to mouse Chromosome 8 at approximately 28 cM with peak marker D8Mit46. Cia16 is linked to soluble CD44 production (LOD=3.3).

(*Authors list D8Mit46 as the marker in close linkage with Cia16, but this MIT marker has been re-named D9Mit1000.)

References

• Original: J:82018 Adarichev VA, et al., Combined autoimmune models of arthritis reveal shared and independent qualitative (binary) and quantitative trait loci. J Immunol. 2003 Mar 1;170(5):2283-92
• All: 1 reference(s)