Pgia25^DBA/1J
QTL Variant Detail

Summary

• QTL variant: Pgia25^DBA/1J
• Name: proteoglycan induced arthritis 25; DBA/1J
• MGI ID: MGI:2656620
• QTL: Pgia25 Location: ChrX:161474380-161474529 bp Genetic Position: ChrX, Syntenic

Variant origin

• Strain of Specimen: DBA/1J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:82018

135 SSLP markers were screened in a set of 939 (BALB/cCrl x DBA/1J)F2 intercross animals to identify QTLs associated with collagen-induced arthritis (CIA) and proteoglycan-induced arthritis (PGIA). Parental strain BALB/cCrl is CIA-resistant and PGIA-susceptible while parental strain DBA/1J is CIA-susceptible and PGIA-resistant.

A major locus was identified on mouse Chromosome 17 in linkage to both CIA (LOD=21) and PGIA (LOD=6). This locus, Pgia17, has been previously identified and maps to proximal Chromosome 17.

Novel loci associated with PGIA, Pgia24 mapped to an interval on mouse Chromosome X spanning 19cM - 30cM, flanked by markers DXMit140 and DXMit119. Pgia 24 is linked to autoantibody production (LOD=5.6) and IgG production (LOD=4.8)

Pgia25 mapped to an interval spanning 50cM - 72cM, flanked by markers DXMit172 and DXMIt31. Pgia25 is linked to IL-1 production (LOD=7.2) and soluble CD22 production (LOD=8.5).

A novel locus associated with CIA, Cia19 (mCia13), maps to mouse Chromosome X in an interval spanning 50cM - 60cM, flanked by markers DXMit172 and DXMit121. Cia19 is linked to total arthritis score (LOD=3.9).

References

• Original: J:82018 Adarichev VA, et al., Combined autoimmune models of arthritis reveal shared and independent qualitative (binary) and quantitative trait loci. J Immunol. 2003 Mar 1;170(5):2283-92
• All: 1 reference(s)