Amot^tm1Bhr
Targeted Allele Detail

Summary

• Symbol: Amot^tm1Bhr
• Name: angiomotin; targeted mutation 1, Richard R Behringer
• MGI ID: MGI:2656627
• Synonyms: X^amot
• Gene: Amot Location: ChrX:144229420-144288145 bp, - strand Genetic Position: ChrX, 66.72 cM
• Alliance: Amot^tm1Bhr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82844
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of the splice acceptor site of the second exon with a PGK-neo cassette via homologous recombination. RT-PCR sequence analysis showed the mutant allele contains a frameshift and premature stop codon, therefore no functional protein product should be translated. (J:82844)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Amot Mutation: 11 strains or lines available

References

• Original: J:82844 Shimono A, et al., Angiomotin Regulates Visceral Endoderm Movements during Mouse Embryogenesis. Curr Biol. 2003 Apr 1;13(7):613-7
• All: 5 reference(s)