Del(2Gm13672-Hoxd11)68Ddu
Targeted Allele Detail

Summary

• Symbol: Del(2Gm13672-Hoxd11)68Ddu
• Name: deletion, Chr2, Dennis Duboule 68; targeted mutation 1, Dennis Duboule
• MGI ID: MGI:2656714
• Synonyms: delII, Evx2/Hoxd11/Hoxd12/Hoxd13^tm1Ddu
• Gene: Del(2Gm13672-Hoxd11)68Ddu Location: unknown Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54543
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(2Gm13672-Hoxd11)68Ddu involves 5 genes/genome features (Gm13672, Evx2, Hoxd13 ...) View all
• Mutation details: A loxP site was inserted 3' of Hoxd11 and a Hoxd9/lacZ/loxP transgene ( Tg(Hoxd9/lacZ/neo)4Ddu) was inserted 26 kb upstream of the Hoxd13 start site via homologous recombination. Mutant animals were mated to cre deleter line Tg(CMV-cre)1Ipc to delete the entire region between the 2 loxP sites, which includes Evx2, Hoxd13, Hoxd12, and Hoxd11. (J:54543)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(2Gm13672-Hoxd11)68Ddu Mutation: 0 strains or lines available

References

• Original: J:54543 Kondo T, et al., Breaking colinearity in the mouse HoxD complex. Cell. 1999 Apr 30;97(3):407-17
• All: 2 reference(s)