Hoxb13^tm3Mrc
Targeted Allele Detail

Summary

• Symbol: Hoxb13^tm3Mrc
• Name: homeobox B13; targeted mutation 3, Mario R Capecchi
• MGI ID: MGI:2656726
• Synonyms: Hoxb13^lacZneo
• Gene: Hoxb13 Location: Chr11:96085142-96087436 bp, + strand Genetic Position: Chr11, 59.63 cM
• Alliance: Hoxb13^tm3Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82849
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ gene was inserted into exon 2 at codon 33, disrupting the homeodomain. The targeting vector included a floxed neo cassette immediately downstream of lacZ. Subsequent in vivo excision of the floxed neo cassette resulted in Hoxb13^tm1Mrc. (J:82849)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxb13 Mutation: 9 strains or lines available

References

• Original: J:82849 Economides KD, et al., Hoxb13 mutations cause overgrowth of caudal spinal cord and tail vertebrae. Dev Biol. 2003 Apr 15;256(2):317-30
• All: 1 reference(s)