Mrc1^tm1Jub
Targeted Allele Detail

Summary

• Symbol: Mrc1^tm1Jub
• Name: mannose receptor, C type 1; targeted mutation 1, Jacques U Baenziger
• MGI ID: MGI:2656742
• Synonyms: M/G4S-R^-
• Gene: Mrc1 Location: Chr2:14234225-14336834 bp, + strand Genetic Position: Chr2, 10.46 cM
• Alliance: Mrc1^tm1Jub page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74332
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 2 with a PGK-neo cassette via homologous recombination. Exon 2 was chosen for targeting because it encodes the entire cysteine-rich domain of the receptor and is the longest contiguous coding sequence. (J:74332)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mrc1 Mutation: 86 strains or lines available

References

• Original: J:74332 Mi Y, et al., Regulation of lutropin circulatory half-life by the mannose/N-acetylgalactosamine-4-SO4 receptor is critical for implantation in vivo. J Clin Invest. 2002 Jan;109(2):269-76
• All: 2 reference(s)