Atoh1^trhl
Chemically induced Allele Detail

Summary

• Symbol: Atoh1^trhl
• Name: atonal bHLH transcription factor 1; trembling with hearing loss
• MGI ID: MGI:2656758
• Gene: Atoh1 Location: Chr6:64706109-64708229 bp, + strand Genetic Position: Chr6, 30.03 cM
• Alliance: Atoh1^trhl page

Cerebellar abnormalities in Atoh1^trhl/Atoh1^trhl mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: 129 x C57BL/6J

Mutation description

Allele Type: Chemically induced (ENU) (Hypomorph) Mutation: Single point mutation Mutation details: ENU mutagenesis induced a G to A point mutation that results in the amino acid substitution of isoleucine for methionine at position 200 (M200I). RT-PCR confirmed reduced transcript expression. (J:209662) Inheritance: Recessive

Identifying the mutation in the Atoh1^trhl allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atoh1 Mutation: 37 strains or lines available

References

• Original: J:209662 Sheykholeslami K, et al., A new mutation of the Atoh1 gene in mice with normal life span allows analysis of inner ear and cerebellar phenotype in aging. PLoS One. 2013;8(11):e79791
• All: 1 reference(s)