Cd74tm3Liz
Targeted Allele Detail
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Symbol: |
Cd74tm3Liz |
Name: |
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); targeted mutation 3, Elizabeth K Bikoff |
MGI ID: |
MGI:2656764 |
Synonyms: |
41 |
Gene: |
Cd74 Location: Chr18:60936921-60945724 bp, + strand Genetic Position: Chr18, 34.41 cM
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Alliance: |
Cd74tm3Liz page
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Germline Transmission: |
Earliest citation of germline transmission:
J:82880
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Parent Cell Line: |
CCE/EK.CCE (ES Cell)
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Strain of Origin: |
129S/SvEv-Gpi1c
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Allele Type: |
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Targeted (Inserted expressed sequence, Modified isoform(s)) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: An allele from which p31 expression is ablated and only p41 is produced, was generated using a hit and run strategy. Genomic sequence was replaced with cDNA sequence encoding exons 5, 6 and 6b, thus eliminating the possiblility for p31-specific splicing. The exclusive expression of p41 was shown in homozygous mutant mice by RNase protection. Immunoprecipitation showed that p41 was expressed at levels higher than those in wild-type mice.
(J:82880)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cd74 Mutation: |
36 strains or lines available
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Original: |
J:82880 Takaesu NT, et al., In vivo functions mediated by the p41 isoform of the MHC class II-associated invariant chain. J Immunol. 1997 Jan 1;158(1):187-99 |
All: |
6 reference(s) |
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