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Cd74tm3Liz
Targeted Allele Detail
Summary
Symbol: Cd74tm3Liz
Name: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); targeted mutation 3, Elizabeth K Bikoff
MGI ID: MGI:2656764
Synonyms: 41
Gene: Cd74  Location: Chr18:60936921-60945724 bp, + strand  Genetic Position: Chr18, 34.41 cM
Alliance: Cd74tm3Liz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82880
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Modified isoform(s))
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn allele from which p31 expression is ablated and only p41 is produced, was generated using a hit and run strategy. Genomic sequence was replaced with cDNA sequence encoding exons 5, 6 and 6b, thus eliminating the possiblility for p31-specific splicing. The exclusive expression of p41 was shown in homozygous mutant mice by RNase protection. Immunoprecipitation showed that p41 was expressed at levels higher than those in wild-type mice. (J:82880)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd74 Mutation:  36 strains or lines available
References
Original:  J:82880 Takaesu NT, et al., In vivo functions mediated by the p41 isoform of the MHC class II-associated invariant chain. J Immunol. 1997 Jan 1;158(1):187-99
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory