Smdq1^CAST/EiJ
QTL Variant Detail

Summary

• QTL variant: Smdq1^CAST/EiJ
• Name: segregation of mitochondrial DNA QTL 1; CAST/EiJ
• MGI ID: MGI:2656795
• QTL: Smdq1 Location: Chr5:114021753-114021986 bp Genetic Position: Chr5, cM position of peak correlated region/allele: 55.72 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: CAST/EiJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased genotypic selection of mtDNA in liver at 3 months of age compared to BALB/c. (J:81446)
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:81446

Genome scan was performed on a (BALB/c x CAST/Ei)F2 intercross population to identify QTLs affecting mitochondrial DNA (mtDNA) segregation. Three loci were mapped to mouse Chromosomes 2, 5, and 6. Smdq1 maps to 61 cM on mouse Chromosome 5 at D5Mit25 (LOD=31.5) in linkage to mtDNA segregation in the liver at 3 months of age and accounts for 35% of the phenotypic variance. CAST/Ei-derived alleles at Smdq1 appear to influence mtDNA segregation in a dominantly-inherited manner. Smdq2 maps to 51.4 cM on mouse Chromosome 2 at D2Mit480 (LOD=4.0) in linkage to mtDNA segregation in the kidney at 3 months of age and accounts for 16% of the phenotypic variance. CAST/Ei-derived alleles appear to be associated with mtDNA segregation at Smdq2 in a recessive manner. Smdq3 maps to 3.6 cM on mouse Chromosome 6 at D6Mit266 (LOD=4.4) in linkage to mtDNA segregation in the spleen at 12 months of age and accounts for 20% of the phenotypic variance.

References

• Original: J:81446 Battersby BJ, et al., Nuclear genetic control of mitochondrial DNA segregation. Nat Genet. 2003 Feb;33(2):183-6
• All: 1 reference(s)