Lgth2^SJL/J
QTL Variant Detail

Summary

• QTL variant: Lgth2^SJL/J
• Name: body length 2; SJL/J
• MGI ID: MGI:2656829
• QTL: Lgth2 Location: Chr2:128173704-128173821 bp Genetic Position: Chr2, cM position of peak correlated region/allele: 62.49 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: SJL/J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:81606

Genome scan was performed on 633 (MRL/MpJ x SJL/J)F2 animals to identify QTLs associated with lean body mass and body length. Parental strain MRL/MpJ exhibits a higher amount of lean body mass compared to parental strain SJL/J. Several lean body mass (Lbm) and body length (Lgth) QTLs were mapped. MRL/MpJ-derived alleles confer increased lean body mass at all Lbm loci. Lbm1, Lbm2, Lgth1, and Lgth2 map to mouse Chromosome 2 at 26.3 cM (LOD=3.6) , 50.3 cM (LOD=9.0), 50.3 cM (LOD=10.8), and 72.1 cM (LOD=9.7), respectively. (Lbm2 and Lgth1 overlap.) Lbm1 is inherited additively while Lbm2 is inherited dominantly. Lgth3 maps to 30.6 cM on mouse Chromosome 4 with LOD=2.7 at D4Mit178. Lbm3 and Lbm4 map to mouse Chromosome 6 at 17.5 cM (LOD=4.7) and 49.2 cM (LOD=4.7), respectively. Lbm3 exhibits a dominant mode of inheritance and Lbm4 exhibits an additive mode of inheritance. Lbm5 maps to 8 cM on mouse Chromosome 7 with LOD=2.9 at D7Mit22 and exhibits an additive mode of inheritance. Lbm6 and Lgth4 both map to 7.7 cM (LOD=7.5 and LOD=4.7, respectively), and Lbm7 and Lgth5 both map to 31.7 cM (LOD=4.7 and LOD=2.3, respectively) on mouse Chromosome 9. Lbm6 and Lbm7 exhibit dominant inheritance. Lgth6 maps to 43.7 cM on mouse Chromosome 11 with LOD=4.8 at D11Mit36. Lbm8and Lgth8 both map to 23 cM (LOD=4.2 and LOD=2.3, respectively), and Lbm9 and Lgth7 both map to 2.2 cM (LOD=3.9 and LOD=2.7, respectively) on mouse Chromosome 13. Lbm8 and Lbm9 exhibit additive inheritance. Lbm10 maps to 40.4 cM on mouse Chromosome 14with LOD=4.7 at D14Mit32 and exhibits additive inheritance.

J:81605

Genome scan was performed on 633 animals from an (MRL/MpJ x SJL/J)F2 cross to identify loci influencing muscle size and body length. 119 markers were screened at an average resolution of 15 cM. Five QTLs showing significant linkage to muscle size (P<0.005) were mapped. Musz1 maps to 5.5 cM on mouse Chromosome 7, Musz2 and Musz3 map to 21.9 cM and 40.4 cM on mouse Chromosome 14, respectively, Musz4 maps to 13.1 cM on mouse Chromosome 15, and Musz5 maps to 41.5 cM on mouse Chromosome 17. These 5 QTLs explain 19.2% of the phenotypic variance. A sixth suggestive QTL mapped to 7.7 cM on mouse Chromosome 9 and appears to influence body length as well as muscle size.

Previously identified body length QTLs were detected in this study: Lgth1 (LOD=6.21 at D2Mit182) and Lgth2 (LOD=8.7 at D2Mit304) on mouse Chromosome 2, Lgth4 (LOD=4.1 at D9Mit90) on mouse Chromosome 9, and Lgth6 (LOD=2.7 at D11Mit36) on mouse Chromosome 11.

A novel body length QTL, Lgth9, mapped to 6.6 cM on mouse Chromosome 17 with LOD=4.1 at D17Mit175.

References

• Original: J:81606 Masinde GL, et al., Quantitative trait loci (QTL) for lean body mass and body length in MRL/MPJ and SJL/J F(2) mice. Funct Integr Genomics. 2002 Aug;2(3):98-104
• All: 2 reference(s)