Summary |
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Variant origin |
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Variant description |
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Phenotypes |
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View phenotypes and curated references for all genotypes (concatenated display).
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:81606Genome scan was performed on 633 (MRL/MpJ x SJL/J)F2 animals to identify QTLs associated with lean body mass and body length. Parental strain MRL/MpJ exhibits a higher amount of lean body mass compared to parental strain SJL/J. Several lean body mass (Lbm) and body length (Lgth) QTLs were mapped. MRL/MpJ-derived alleles confer increased lean body mass at all Lbm loci. Lbm1, Lbm2, Lgth1, and Lgth2 map to mouse Chromosome 2 at 26.3 cM (LOD=3.6) , 50.3 cM (LOD=9.0), 50.3 cM (LOD=10.8), and 72.1 cM (LOD=9.7), respectively. (Lbm2 and Lgth1 overlap.) Lbm1 is inherited additively while Lbm2 is inherited dominantly. Lgth3 maps to 30.6 cM on mouse Chromosome 4 with LOD=2.7 at D4Mit178. Lbm3 and Lbm4 map to mouse Chromosome 6 at 17.5 cM (LOD=4.7) and 49.2 cM (LOD=4.7), respectively. Lbm3 exhibits a dominant mode of inheritance and Lbm4 exhibits an additive mode of inheritance. Lbm5 maps to 8 cM on mouse Chromosome 7 with LOD=2.9 at D7Mit22 and exhibits an additive mode of inheritance. Lbm6 and Lgth4 both map to 7.7 cM (LOD=7.5 and LOD=4.7, respectively), and Lbm7 and Lgth5 both map to 31.7 cM (LOD=4.7 and LOD=2.3, respectively) on mouse Chromosome 9. Lbm6 and Lbm7 exhibit dominant inheritance. Lgth6 maps to 43.7 cM on mouse Chromosome 11 with LOD=4.8 at D11Mit36. Lbm8and Lgth8 both map to 23 cM (LOD=4.2 and LOD=2.3, respectively), and Lbm9 and Lgth7 both map to 2.2 cM (LOD=3.9 and LOD=2.7, respectively) on mouse Chromosome 13. Lbm8 and Lbm9 exhibit additive inheritance. Lbm10 maps to 40.4 cM on mouse Chromosome 14with LOD=4.7 at D14Mit32 and exhibits additive inheritance. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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