Sgca^tm1Eeng
Targeted Allele Detail

Summary

• Symbol: Sgca^tm1Eeng
• Name: sarcoglycan, alpha (dystrophin-associated glycoprotein); targeted mutation 1, Eva Engvall
• MGI ID: MGI:2656910
• Synonyms: ASG -
• Gene: Sgca Location: Chr11:94853617-94867153 bp, - strand Genetic Position: Chr11, 59.01 cM, cytoband C
• Alliance: Sgca^tm1Eeng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59165
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Portions of exons 1 and 2 and all of intron 1 were replaced with a cassette containing lacZ and neo. The absence of normal protein in homozygous mutant mice was verified by immunofluorescence and Western blot analysis. (J:59165)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sgca Mutation: 26 strains or lines available

Notes

ES cell line = SM38.

References

• Original: J:59165 Liu LA, et al., Sarcoglycan isoforms in skeletal muscle. J Biol Chem. 1999 Dec 31;274(53):38171-6
• All: 5 reference(s)