Selenop^tm1Rfb
Targeted Allele Detail

Summary

• Symbol: Selenop^tm1Rfb
• Name: selenoprotein P; targeted mutation 1, Raymond F Burk
• MGI ID: MGI:2656912
• Synonyms: Sepp^-
• Gene: Selenop Location: Chr15:3300249-3309992 bp, + strand Genetic Position: Chr15, 1.84 cM
• Alliance: Selenop^tm1Rfb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82921
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 2 via homologous recombination. The neo cassette carries stop codons in all 3 reading frames. Protein product was undetectable by Western blot and radioimmunoassay of plasma samples from homozygous mutant animals. (J:82921)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Selenop Mutation: 24 strains or lines available

References

• Original: J:82921 Hill KE, et al., Deletion of selenoprotein P alters distribution of selenium in the mouse. J Biol Chem. 2003 Apr 18;278(16):13640-6
• All: 34 reference(s)