Por^tm1Wolf
Targeted Allele Detail

Summary

• Symbol: Por^tm1Wolf
• Name: cytochrome p450 oxidoreductase; targeted mutation 1, C Roland Wolf
• MGI ID: MGI:2656919
• Synonyms: CPR^lox, HRN, POR^lox
• Gene: Por Location: Chr5:135698894-135764180 bp, + strand Genetic Position: Chr5, 75.34 cM, cytoband G1
• Alliance: Por^tm1Wolf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82951
• Parent Cell Line: GK129 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was introduced into intron 4 and a single loxP site was introduced into intron 15 via homologous recombination. (J:82951)

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Por Mutation: 80 strains or lines available

Notes

The HRN (Hepatic cytochrome P450 Reductase Null) synonym is a trade mark for the conditional liver knockout of homozygous mice produced in conjunction with Tg(Alb-cre)21Mgn.

References

• Original: J:82951 Henderson CJ, et al., Inactivation of the hepatic cytochrome p450 system by conditional deletion of hepatic cytochrome p450 reductase. J Biol Chem. 2003 Apr 11;278(15):13480-6
• All: 10 reference(s)