Socs1^tm3.1Wehi
Targeted Allele Detail

Summary

• Symbol: Socs1^tm3.1Wehi
• Name: suppressor of cytokine signaling 1; targeted mutation 3.1, Walter and Eliza Hall Institute of Medical Research
• MGI ID: MGI:2656956
• Synonyms: SOCS-1^CMV-lox
• Gene: Socs1 Location: Chr16:10601672-10603400 bp, - strand Genetic Position: Chr16, 5.81 cM
• Alliance: Socs1^tm3.1Wehi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83009
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A null allele was generated by removing a floxed fragment containing the entire gene by cre-mediated recombination in the germline. Human CD4-polyA and an FRT flanked hygro cassette remained after excision. (J:83009)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Socs1 Mutation: 30 strains or lines available

References

• Original: J:83009 Chong MM, et al., Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation. Immunity. 2003 Apr;18(4):475-87
• All: 1 reference(s)