Ahr^tm1Yfk
Targeted Allele Detail

Summary

• Symbol: Ahr^tm1Yfk
• Name: aryl-hydrocarbon receptor; targeted mutation 1, Yoshiaki Fujii-Kuriyama
• MGI ID: MGI:2657000
• Synonyms: Ahr^-, Ahr KO
• Gene: Ahr Location: Chr12:35547978-35584988 bp, - strand Genetic Position: Chr12, 15.78 cM
• Alliance: Ahr^tm1Yfk page

Urate stones in the urinary bladder of Ahr^tm1Yfk/Ahr^tm1Yfk mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46346
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The gene was disrupted by introducing an in-frame lacZ-neo fusion to exon 1 via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis of liver RNA. (J:46346)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Ahr Mutation: 112 strains or lines available

References

• Original: J:46346 Mimura J, et al., Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor. Genes Cells. 1997 Oct;2(10):645-54
• All: 34 reference(s)