Nr1i3^tm1Ddm
Targeted Allele Detail

Summary

• Symbol: Nr1i3^tm1Ddm
• Name: nuclear receptor subfamily 1, group I, member 3; targeted mutation 1, David D Moore
• MGI ID: MGI:2657124
• Synonyms: CAR^-
• Gene: Nr1i3 Location: Chr1:171041503-171046414 bp, + strand Genetic Position: Chr1, 79.21 cM
• Alliance: Nr1i3^tm1Ddm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65416
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 1 and exon 2 (which encodes part of the DNA-binding domain) with a lacZ-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot analysis. (J:65416)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Nr1i3^tm1Ddm

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr1i3 Mutation: 36 strains or lines available

References

• Original: J:65416 Wei P, et al., The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature. 2000 Oct 19;407(6806):920-3
• All: 61 reference(s)