Ifnb1^tm1Tl
Targeted Allele Detail

Summary

• Symbol: Ifnb1^tm1Tl
• Name: interferon beta 1, fibroblast; targeted mutation 1, Tomas Leanderson
• MGI ID: MGI:2657141
• Synonyms: IFN-beta-, IFN-beta⁰, Ifnb^{tm1(Lambda2 (315))GBF}
• Gene: Ifnb1 Location: Chr4:88440262-88441011 bp, - strand Genetic Position: Chr4, 41.91 cM
• Alliance: Ifnb1^tm1Tl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83172
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a neo-derived cassette into the region encoding the first 4 amino acids. The targeting construct includes a mouse immunoglobulin lambda 2 reporter sequence. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis of mouse embryonic fibroblasts. (J:83172)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ifnb1 Mutation: 21 strains or lines available

References

• Original: J:83172 Erlandsson L, et al., Interferon-beta is required for interferon-alpha production in mouse fibroblasts. Curr Biol. 1998 Feb 12;8(4):223-6
• All: 33 reference(s)