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Il4ratm1Fbb
Targeted Allele Detail
Summary
Symbol: Il4ratm1Fbb
Name: interleukin 4 receptor, alpha; targeted mutation 1, Frank Brombacher
MGI ID: MGI:2657172
Synonyms: IL-4R-, il4ra-, IL-4Ralpha-, IL-4Ralpha KO
Gene: Il4ra  Location: Chr7:125151443-125178646 bp, + strand  Genetic Position: Chr7, 68.94 cM
Alliance: Il4ratm1Fbb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:55526
Parent Cell Line:  BALB/c-I (ES Cell)
Strain of Origin:  BALB/cJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 7 through 9 were replaced with a single loxP site after homologous recombination and cre-mediate excision. The deleted region encoded the transmembrane, the soluble, and extracelluar membrane proximal regions. FACS analysis and assays of sera indicated a lack of an appreciable amount of both membrane-bound and soluble protein in homozygous mutant mice. (J:55526)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il4ra Mutation:  46 strains or lines available
References
Original:  J:55526 Mohrs M, et al., Differences between IL-4- and IL-4 receptor alpha-deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling. J Immunol. 1999 Jun 15;162(12):7302-8
All:  114 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory