Il4ra^tm1Fbb
Targeted Allele Detail

Summary

• Symbol: Il4ra^tm1Fbb
• Name: interleukin 4 receptor, alpha; targeted mutation 1, Frank Brombacher
• MGI ID: MGI:2657172
• Synonyms: IL-4R^-, il4ra^-, IL-4Ralpha-, IL-4Ralpha KO
• Gene: Il4ra Location: Chr7:125151443-125178646 bp, + strand Genetic Position: Chr7, 68.94 cM
• Alliance: Il4ra^tm1Fbb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55526
• Parent Cell Line: BALB/c-I (ES Cell)
• Strain of Origin: BALB/cJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 7 through 9 were replaced with a single loxP site after homologous recombination and cre-mediate excision. The deleted region encoded the transmembrane, the soluble, and extracelluar membrane proximal regions. FACS analysis and assays of sera indicated a lack of an appreciable amount of both membrane-bound and soluble protein in homozygous mutant mice. (J:55526)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il4ra Mutation: 46 strains or lines available

References

• Original: J:55526 Mohrs M, et al., Differences between IL-4- and IL-4 receptor alpha-deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling. J Immunol. 1999 Jun 15;162(12):7302-8
• All: 114 reference(s)