Il4ratm1Fbb
Targeted Allele Detail
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Symbol: |
Il4ratm1Fbb |
Name: |
interleukin 4 receptor, alpha; targeted mutation 1, Frank Brombacher |
MGI ID: |
MGI:2657172 |
Synonyms: |
IL-4R-, il4ra-, IL-4Ralpha-, IL-4Ralpha KO |
Gene: |
Il4ra Location: Chr7:125151443-125178646 bp, + strand Genetic Position: Chr7, 68.94 cM
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Alliance: |
Il4ratm1Fbb page
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Germline Transmission: |
Earliest citation of germline transmission:
J:55526
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Parent Cell Line: |
BALB/c-I (ES Cell)
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Strain of Origin: |
BALB/cJ
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 7 through 9 were replaced with a single loxP site after homologous recombination and cre-mediate excision. The deleted region encoded the transmembrane, the soluble, and extracelluar membrane proximal regions. FACS analysis and assays of sera indicated a lack of an appreciable amount of both membrane-bound and soluble protein in homozygous mutant mice.
(J:55526)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Il4ra Mutation: |
46 strains or lines available
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Original: |
J:55526 Mohrs M, et al., Differences between IL-4- and IL-4 receptor alpha-deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling. J Immunol. 1999 Jun 15;162(12):7302-8 |
All: |
114 reference(s) |
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