Jag2^tm1Grid
Targeted Allele Detail

Summary

• Symbol: Jag2^tm1Grid
• Name: jagged 2; targeted mutation 1, Tom Gridley
• MGI ID: MGI:2657215
• Synonyms: Jag2^-, Jag2^deltaDSL
• Gene: Jag2 Location: Chr12:112871439-112893396 bp, - strand Genetic Position: Chr12, 61.37 cM
• Alliance: Jag2^tm1Grid page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46930
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of a 5 kb region with a PGK-neo cassette via recombination resulting in deletion of the DSL domain and half of the first EGF repeat. The absence of the DSL domain-containing sequence was confirmed by Southern blot analysis. (J:46930)
• Inheritance: Not Specified

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Jag2 Mutation: 44 strains or lines available

References

• Original: J:46930 Jiang R, et al., Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice. Genes Dev. 1998 Apr 1;12(7):1046-57
• All: 16 reference(s)