Brs3^tm1Jfb
Targeted Allele Detail

Summary

• Symbol: Brs3^tm1Jfb
• Name: bombesin-like receptor 3; targeted mutation 1, James F Battey
• MGI ID: MGI:2657217
• Synonyms: BRS-3 KO
• Gene: Brs3 Location: ChrX:56088434-56094118 bp, + strand Genetic Position: ChrX, 30.78 cM, cytoband A7.1-A7.2
• Alliance: Brs3^tm1Jfb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134021
• Parent Cell Line: GSI-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 has been replaced with a neomycin resistance cassette. No transcript from the disrupted gene was detected in mRNA from brains of homozygous mutant mice by reverse transcription followed by PCR analysis (RT-PCR). (J:134021)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Brs3 Mutation: 14 strains or lines available

References

• Original: J:134021 Ladenheim EE, et al., Factors contributing to obesity in bombesin receptor subtype-3-deficient mice. Endocrinology. 2008 Mar;149(3):971-8
• All: 7 reference(s)