Hpgd^tm1Bhk
Targeted Allele Detail

Summary

• Symbol: Hpgd^tm1Bhk
• Name: hydroxyprostaglandin dehydrogenase 15 (NAD); targeted mutation 1, Beverly H Koller
• MGI ID: MGI:2657242
• Synonyms: Pgdh^-
• Gene: Hpgd Location: Chr8:56747620-56774078 bp, + strand Genetic Position: Chr8, 29.7 cM, cytoband B3.2
• Alliance: Hpgd^tm1Bhk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74466
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of sequences corresponding to amino acids 167-266 of the human protein with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot analysis of lung and liver RNA. (J:74466)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hpgd Mutation: 24 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Patent Ductus Arteriosus in homozygous mice (J:74466)

References

• Original: J:74466 Coggins KG, et al., Metabolism of PGE2 by prostaglandin dehydrogenase is essential for remodeling the ductus arteriosus. Nat Med. 2002 Feb;8(2):91-2
• All: 9 reference(s)