Iglc1^tm2Ust
Targeted Allele Detail

Summary

• Symbol: Iglc1^tm2Ust
• Name: immunoglobulin lambda constant 1; targeted mutation 2, Ursula Storb
• MGI ID: MGI:2657246
• Synonyms: Igl-C1^tm1Ust, lambda1-val, V-n
• Gene: Iglc1 Location: Chr16:18880502-18880821 bp, - strand Genetic Position: Chr16, 11.8 cM
• Alliance: Iglc1^tm2Ust page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74717
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Nucleotide substitutions
• Mutation details: A glycine to valine substitution was introduced to amino acid 154 (G154V) via homologous recombination. A PGK-neo cassette was inserted upstream of the J lambda 1 element for positive selection. The gene targeting event was confirmed by Southern blot analysis. (J:74717)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Iglc1 Mutation: 4 strains or lines available

References

• Original: J:74717 Sun T, et al., A Point Mutation in the Constant Region of Ig Lambda1 Prevents Normal B Cell Development due to Defective BCR Signaling. Immunity. 2002 Feb;16(2):245-55
• All: 2 reference(s)