Atrn^mg-6J
Spontaneous Allele Detail

Summary

• Symbol: Atrn^mg-6J
• Name: attractin; mahogany 6 Jackson
• MGI ID: MGI:2657306
• Gene: Atrn Location: Chr2:130748415-130872253 bp, + strand Genetic Position: Chr2, 63.26 cM
• Alliance: Atrn^mg-6J page

Mutation origin

• Strain of Origin: CAST/EiJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion
• Mutation details: This mutation has a genomic deletion which encompasses much of the Atrn gene including the N-terminus, but not the C-terminus. The last two coding exons are not deleted. Northern blot analysis of total brain RNA failed to detect Atrn transcript in mice homozygous for this allele. (J:96070)
• Inheritance: Recessive

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Atrn^mg-6J/Atrn^mg-6J	CAST/Ei-Atrn^mg-6J
hm2	Atrn^mg-6J/Atrn^mg-6J	involves: C3H/HeSnJ * CAST/Ei

Phenotypes:

Affected Systems	hm1	hm2
show or hide all annotated terms
behavior/neurological	√	√
tremors	√	√
abnormal gait	√
integument	√	√
darkened coat color	√	√
mortality/aging	√
premature death	√
nervous system	√	√
abnormal brain morphology		√
abnormal brain white matter morphology		√
abnormal medulla oblongata morphology		√
abnormal thalamus morphology		√
abnormal cerebral cortex morphology		√
abnormal cerebellum morphology		√
brain vacuoles		√
abnormal neuron morphology	√
abnormal spinal cord white matter morphology		√
pigmentation	√	√
darkened coat color	√	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atrn Mutation: 90 strains or lines available

References

• Original: J:96070 Bronson RT, et al., Mice with mutations in the mahogany gene Atrn have cerebral spongiform changes. J Neuropathol Exp Neurol. 2001 Jul;60(7):724-30
• All: 2 reference(s)