H2^dlAb1-Ea
Targeted Allele Detail

Summary

• Symbol: H2^dlAb1-Ea
• Name: histocompatibility-2, MHC; targeted deletion, H2 complex
• MGI ID: MGI:2658725
• Synonyms: ABeta^o, (IA IE)^null, II^delta, MHC class II^delta, MHC II^-, MHCII^-, MHC II⁰, MHC II^delta, MHC-II^delta, MHCII^delta, MHC II KO
• Gene: H2 Location: unknown Genetic Position: Chr17, cytoband B-C

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57484
• Parent Cell Line: H1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intergenic deletion
• H2^dlAb1-Ea involves 5 genes/genome features (H2-Ab1, H2-Aa, H2-Eb1 ...) View all
• Mutation details: A 78.8 kb deletion disrupting Class II MHC genes was induced in 129S2/SvPas-derived H1 embryonic stem (ES) cells via Cre recombination. A hygro-resistance cassette was inserted at the deletion site. The deletion spans from the second exon of the H2-Ab1 gene the third exon of the H2-Ea gene. The H2-Aa, H2-Eb1 and H2-Eb2 genes are completely deleted. (J:57484)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 13 strains available Cell Lines: 0 lines available
• Carrying any H2 Mutation: 282 strains or lines available

References

• Original: J:57484 Madsen L, et al., Mice lacking all conventional MHC class II genes. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10338-43
• All: 222 reference(s)