Fglu2^KK
QTL Variant Detail

Summary

• QTL variant: Fglu2^KK
• Name: fasting glucose 2; KK
• MGI ID: MGI:2660578
• Synonyms: Fglu2^KK-Ay
• QTL: Fglu2 Location: Chr1:174456299-174456436 bp Genetic Position: Chr1, cM position of peak correlated region/allele: 81.08 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: KK

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confer increased fasting plasma glucose concentration compared to C57BL/6J. (J:81517)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:81517

91 female animals from a (C57BL/6J x KK-A^y)F2 intercross were screened for 97 microsatellite markers at an average spacing of 16.5 cM to identify QTLs associated with hyperglycemia, glucose tolerance, and fasting plasma insulin. Parental strain KK-A^yexhibits non-insulin dependent diabetes mellitus (NIDDM) with mild obesity compared to the normoglycemic lean parental strain C57BL/6J.

A QTL associated with glucose intolerance, Giq1, mapped to 21 cM on mouse Chromosome 8 with LOD=5.6 at D8Mit191. Giq1shows a strong effect in the late phase of the intraperitoneal glucose tolerance test (IPGTT) and explains approximately 24.5% of the phenotypic variance. KK-derived alleles confer increased glucose concentration at 120 minutes of the IPGTT. Candidate genes mapping near Giq1 include Npy5r, Cpe, Lpl, and Ucp1. The Giq1 locus is sytenic to human chromosome 3p22-p21.3 or 8p22-p21.3.

Suggestive linkages were also detected at 100 cM on mouse Chromosome 1 with LOD=3.6 at D1Mit150 for fasting glucose levels (Fglu2), at 44.5 cM on mouse Chromosome 4 with LOD=2.9 at D4Mit166 for glucose intolerance (Gauc), and at 71.8 cM on mouse Chromosome 3 with LOD=3.9 at D3Mit84 for fasting plasma insulin (Fpli). The KK-derived allele confers increased glucose concentrationsat D1Mit150 and D4Mit166 loci whereas the C57BL/6J-derived allele confers increased plasma insulin levels at D3Mit84.

References

• Original: J:81517 Suto J, et al., A quantitative trait locus that accounts for glucose intolerance maps to chromosome 8 in hereditary obese KK-A(y) mice. Int J Obes Relat Metab Disord. 2002 Nov;26(11):1517-9
• All: 1 reference(s)