Musz3^MRL/MpJ
QTL Variant Detail

Summary

• QTL variant: Musz3^MRL/MpJ
• Name: muscle size 3; MRL/MpJ
• MGI ID: MGI:2660647
• QTL: Musz3 Location: unknown Genetic Position: Chr14, Syntenic

Variant origin

• Strain of Specimen: MRL/MpJ

Variant description

• Allele Type: QTL

Notes

Musz2 and Musz3 interact to affect muscle size.

Animals homozygous for MRL/MpJ-derived alleles at Musz2 and homozygous for SJL/J-derived alleles at Musz3 display significantly increased muscle size compared to all other allele combination.

Animals homozygous for SJL/J-derived alleles at both Musz2 and Musz3 display significantly decreased muscle size compared to all other allele combination.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:81605

Genome scan was performed on 633 animals from an (MRL/MpJ x SJL/J)F2 cross to identify loci influencing muscle size and body length. 119 markers were screened at an average resolution of 15 cM. Five QTLs showing significant linkage to muscle size (P<0.005) were mapped. Musz1 maps to 5.5 cM on mouse Chromosome 7, Musz2 and Musz3 map to 21.9 cM and 40.4 cM on mouse Chromosome 14, respectively, Musz4 maps to 13.1 cM on mouse Chromosome 15, and Musz5 maps to 41.5 cM on mouse Chromosome 17. These 5 QTLs explain 19.2% of the phenotypic variance. A sixth suggestive QTL mapped to 7.7 cM on mouse Chromosome 9 and appears to influence body length as well as muscle size.

Previously identified body length QTLs were detected in this study: Lgth1 (LOD=6.21 at D2Mit182) and Lgth2 (LOD=8.7 at D2Mit304) on mouse Chromosome 2, Lgth4 (LOD=4.1 at D9Mit90) on mouse Chromosome 9, and Lgth6 (LOD=2.7 at D11Mit36) on mouse Chromosome 11.

A novel body length QTL, Lgth9, mapped to 6.6 cM on mouse Chromosome 17 with LOD=4.1 at D17Mit175.

References

• Original: J:81605 Masinde GL, et al., Quantitative trait loci that harbor genes regulating muscle size in (MRL/MPJ x SJL/J) F(2) mice. Funct Integr Genomics. 2002 Aug;2(3):120-5
• All: 1 reference(s)