Bmx^tm1Ali
Targeted Allele Detail

Summary

• Symbol: Bmx^tm1Ali
• Name: BMX non-receptor tyrosine kinase; targeted mutation 1, Kari Alitalo
• MGI ID: MGI:2660714
• Synonyms: Bmx^-, Bmx^lacZ
• Gene: Bmx Location: ChrX:162975838-163041189 bp, - strand Genetic Position: ChrX, 76.12 cM, cytoband F
• Alliance: Bmx^tm1Ali page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74967
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 2, which contains the translation initiation site, with a lacZ-neo cassette via homologous recombination. Absence of gene expression was confirmed by RT-PCR analysis of bone marrow RNA from homozygous mutant mice. (J:74967)

Expression

In Mice Carrying this Mutation:	83 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bmx Mutation: 12 strains or lines available

References

• Original: J:74967 Rajantie I, et al., Bmx tyrosine kinase has a redundant function downstream of angiopoietin and vascular endothelial growth factor receptors in arterial endothelium. Mol Cell Biol. 2001 Jul;21(14):4647-55
• All: 10 reference(s)