Pou3f3^tm1Rmc
Targeted Allele Detail

Summary

• Symbol: Pou3f3^tm1Rmc
• Name: POU domain, class 3, transcription factor 3; targeted mutation 1, Robert J McEvilly
• MGI ID: MGI:2660725
• Synonyms: Brn-1^-
• Gene: Pou3f3 Location: Chr1:42734928-42739370 bp, + strand Genetic Position: Chr1, 21.21 cM
• Alliance: Pou3f3^tm1Rmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74989
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of sequences encoding the first 476 amino acids with a PGK-neo cassette via homologous recombination. The gene targeting event was confirmed by Southern blot analysis. Immunohistochemical analysis of homozygous mutant brains failed to detect protein product. (J:74989)

Expression

In Mice Carrying this Mutation:	71 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pou3f3 Mutation: 12 strains or lines available

References

• Original: J:74989 McEvilly RJ, et al., Transcriptional regulation of cortical neuron migration by POU domain factors. Science. 2002 Feb 22;295(5559):1528-32
• All: 2 reference(s)