Gab2^tm1Thir
Targeted Allele Detail

Summary

• Symbol: Gab2^tm1Thir
• Name: growth factor receptor bound protein 2-associated protein 2; targeted mutation 1, Toshio Hirano
• MGI ID: MGI:2660754
• Synonyms: Gab2^-
• Gene: Gab2 Location: Chr7:96730958-96958158 bp, + strand Genetic Position: Chr7, 53.39 cM, cytoband E2
• Alliance: Gab2^tm1Thir page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75092
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon encoding a major portion of the pleckstrin homology (PH) domain (amino acids 28-128) was replaced with a neomycin resistance gene via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of testis proteins. (J:75092)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gab2 Mutation: 37 strains or lines available

References

• Original: J:75092 Nishida K, et al., Requirement of Gab2 for mast cell development and KitL/c-Kit signaling. Blood. 2002 Mar 1;99(5):1866-9
• All: 16 reference(s)