Gfi1^tm1Tmo
Targeted Allele Detail

Summary

• Symbol: Gfi1^tm1Tmo
• Name: growth factor independent 1 transcription repressor; targeted mutation 1, Tarik Moroy
• MGI ID: MGI:2660761
• Synonyms: Gfi1^Deltaex2-5
• Gene: Gfi1 Location: Chr5:107864521-107873671 bp, - strand Genetic Position: Chr5, 52.23 cM
• Alliance: Gfi1^tm1Tmo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75143
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exons 2-4, and part of exon 5, with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of thymus proteins. (J:75143)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gfi1 Mutation: 31 strains or lines available

References

• Original: J:75143 Karsunky H, et al., Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1. Nat Genet. 2002 Mar;30(3):295-300
• All: 27 reference(s)