Clps^tm1Lowe
Targeted Allele Detail

Summary

• Symbol: Clps^tm1Lowe
• Name: colipase, pancreatic; targeted mutation 1, Mark E Lowe
• MGI ID: MGI:2660767
• Synonyms: Clps^-
• Gene: Clps Location: Chr17:28777184-28779740 bp, - strand Genetic Position: Chr17, 14.76 cM, cytoband B1
• Alliance: Clps^tm1Lowe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75167
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 1 and part of intron 1 with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Northern and Western blot analysis of samples from the pancreas, stomach, and small intestines. (J:75167)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clps Mutation: 11 strains or lines available

References

• Original: J:75167 D'Agostino D, et al., Decreased postnatal survival and altered body weight regulation in procolipase-deficient mice. J Biol Chem. 2002 Mar 1;277(9):7170-7
• All: 2 reference(s)