Jun^{tm5.1(Junb)Wag}
Targeted Allele Detail

Summary

• Symbol: Jun^{tm5.1(Junb)Wag}
• Name: jun proto-oncogene; targeted mutation 5.1, Erwin F Wagner
• MGI ID: MGI:2660773
• Synonyms: Jun^ki, Jun^tm1(Junb)Wag
• Gene: Jun Location: Chr4:94937273-94940459 bp, - strand Genetic Position: Chr4, 43.34 cM, cytoband C5-C7
• Alliance: Jun^{tm5.1(Junb)Wag} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75359
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire gene coding region was deleted and replaced with a Junb floxed PGK-neo knock-in cassette via homologous recombination. The floxed neo cassette was removed by transient expression of cre recombinase in correctly targeted ES cells. Northern blot analysis confirmed the expression pattern of the Junb knock-in sequence follows that of the endogenous gene. (J:75359)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jun Mutation: 12 strains or lines available

References

• Original: J:75359 Passegue E, et al., JunB can substitute for Jun in mouse development and cell proliferation. Nat Genet. 2002 Feb;30(2):158-66
• All: 1 reference(s)