Tial1^tm1Mst
Targeted Allele Detail

Summary

• Symbol: Tial1^tm1Mst
• Name: Tia1 cytotoxic granule-associated RNA binding protein-like 1; targeted mutation 1, Michel Streuli
• MGI ID: MGI:2660803
• Synonyms: tiar^-
• Gene: Tial1 Location: Chr7:128041501-128063441 bp, - strand Genetic Position: Chr7, 70.2 cM, cytoband F4
• Alliance: Tial1^tm1Mst page

Lack of germ cells in Tial1^tm1Mst/Tial1^tm1Mst mouse testes and ovaries

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46239
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 5' portion of exon 6 was replaced with a neo cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of extracts from homozygous mutant ES cells. (J:46239)

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tial1 Mutation: 22 strains or lines available

References

• Original: J:46239 Beck ARP, et al., RNA-binding protein TIAR is essential for primordial germ cell development. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2331-6
• All: 3 reference(s)