Arg1^tm1Rki
Targeted Allele Detail

Summary

• Symbol: Arg1^tm1Rki
• Name: arginase, liver; targeted mutation 1, Ramaswamy K Iyer
• MGI ID: MGI:2660809
• Synonyms: AI -
• Gene: Arg1 Location: Chr10:24791105-24803368 bp, - strand Genetic Position: Chr10, 12.26 cM
• Alliance: Arg1^tm1Rki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83263
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing exon 4. Activity assays demonstrated that no functional protein was made from this allele. (J:83263)

Disease models

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Arg1 Mutation: 28 strains or lines available

References

• Original: J:83263 Iyer RK, et al., Mouse model for human arginase deficiency. Mol Cell Biol. 2002 Jul;22(13):4491-8
• All: 20 reference(s)