Slc15a2^tm1Dan
Targeted Allele Detail

Summary

• Symbol: Slc15a2^tm1Dan
• Name: solute carrier family 15 (H+/peptide transporter), member 2; targeted mutation 1, Hannelore Daniel
• MGI ID: MGI:2661036
• Synonyms: Pept2^-, Pept2^lacZ
• Gene: Slc15a2 Location: Chr16:36570539-36605324 bp, - strand Genetic Position: Chr16, 25.97 cM
• Alliance: Slc15a2^tm1Dan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83166
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region of exon 1 was replaced with lacZ. The floxed neo selection cassette was excised in vivo. Northern and Western blot analyses indicated an absence of normal transcript and protein in homozygous mutant mice. Expression of lacZ was driven by the endogenous promoter. (J:83166)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc15a2 Mutation: 65 strains or lines available

References

• Original: J:83166 Rubio-Aliaga I, et al., Targeted disruption of the peptide transporter Pept2 gene in mice defines its physiological role in the kidney. Mol Cell Biol. 2003 May;23(9):3247-52
• All: 4 reference(s)