Dsg4^lah-J
Spontaneous Allele Detail

Summary

• Symbol: Dsg4^lah-J
• Name: desmoglein 4; lanceolate hair Jackson
• MGI ID: MGI:2661039
• Gene: Dsg4 Location: Chr18:20569232-20604878 bp, + strand Genetic Position: Chr18, 11.35 cM
• Alliance: Dsg4^lah-J page

Mutation origin

• Strain of Origin: DBA/1LacJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Insertion
• Mutation details: A spontaneous mutant found to be allelic to lah by complementation testing. The mutation in lah^J allele was identified as a single base insertion within exon 7 at following nucleotide 746. The frameshift creates a premature termination codon resulting in an unstable mRNA product. (J:83118)

Disease models

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dsg4 Mutation: 86 strains or lines available

References

• Original: J:83117 Sundberg JP, et al., Lanceolate hair-J (lahJ): a mouse model for human hair disorders. Exp Dermatol. 2000 Jun;9(3):206-18
• All: 3 reference(s)