Otx1^tm4(cre)Asim
Targeted Allele Detail

Summary

• Symbol: Otx1^tm4(cre)Asim
• Name: orthodenticle homeobox 1; targeted mutation 4, Antonio Simeone
• MGI ID: MGI:2661060
• Synonyms: Otx1^cre
• Gene: Otx1 Location: Chr11:21944764-21952897 bp, - strand Genetic Position: Chr11, 14.1 cM
• Alliance: Otx1^tm4(cre)Asim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83110
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Otx1^tm4(cre)Asim expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Otx1 (MGI:97450)

• Mutation details: Exon 2 and part of exon 1 were deleted and replaced with a cre-neo cassette via homologous recombination, resulting in cre expression under Otx1 regulatory elements. (J:83110)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Otx1 (mouse) Summary of all recombinase alleles driven by Otx1. Alliance mouse Otx1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Otx1 Mutation: 86 strains or lines available

References

• Original: J:83110 Puelles E, et al., Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain. Nat Neurosci. 2003 May;6(5):453-60
• All: 4 reference(s)