Gdf6^tm1Kng
Targeted Allele Detail

Summary

• Symbol: Gdf6^tm1Kng
• Name: growth differentiation factor 6; targeted mutation 1, David M Kingsley
• MGI ID: MGI:2661063
• Synonyms: Gdf6^-
• Gene: Gdf6 Location: Chr4:9844372-9862345 bp, + strand Genetic Position: Chr4, 4.35 cM
• Alliance: Gdf6^tm1Kng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83132
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded the entire mature signalling region and 120 amino acids of the pro region. (J:83132)

Disease models

Expression

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gdf6 Mutation: 26 strains or lines available

References

• Original: J:83132 Settle SH Jr, et al., Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes. Dev Biol. 2003 Feb 1;254(1):116-30
• All: 5 reference(s)