Otx2^tm6Asim
Targeted Allele Detail

Summary

• Symbol: Otx2^tm6Asim
• Name: orthodenticle homeobox 2; targeted mutation 6, Antonio Simeone
• MGI ID: MGI:2661065
• Synonyms: Otx2^flox
• Gene: Otx2 Location: Chr14:48894238-48905101 bp, - strand Genetic Position: Chr14, 25.36 cM
• Alliance: Otx2^tm6Asim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83110
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A a single loxP site was inserted upstream of exon 2 and floxed PGK-neo was inserted downstream of exon 2 via homologous recombination. Cre-mediated recombination removed the selection cassette. (J:83110)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Otx2 Mutation: 50 strains or lines available

References

• Original: J:83110 Puelles E, et al., Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain. Nat Neurosci. 2003 May;6(5):453-60
• All: 14 reference(s)