Otx2^tm6.1Asim
Targeted Allele Detail

Summary

• Symbol: Otx2^tm6.1Asim
• Name: orthodenticle homeobox 2; targeted mutation 6.1, Antonio Simeone
• MGI ID: MGI:2661067
• Synonyms: Otx2^-
• Gene: Otx2 Location: Chr14:48894238-48905101 bp, - strand Genetic Position: Chr14, 25.36 cM
• Alliance: Otx2^tm6.1Asim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83110
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The area contained between loxP sites, which include exon 2 and a PGK-neo cassette, was removed by cre-mediated recombination. (J:83110)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Otx2 Mutation: 50 strains or lines available

References

• Original: J:83110 Puelles E, et al., Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain. Nat Neurosci. 2003 May;6(5):453-60
• All: 1 reference(s)