Itgal^tm1Bll
Targeted Allele Detail

Summary

• Symbol: Itgal^tm1Bll
• Name: integrin alpha L; targeted mutation 1, Christie M Ballantyne
• MGI ID: MGI:2661083
• Synonyms: Cd11a(-), CD11alpha KO, LFA-1^-
• Gene: Itgal Location: Chr7:126895432-126934310 bp, + strand Genetic Position: Chr7, 69.44 cM
• Alliance: Itgal^tm1Bll page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83226
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a neomycin selection casssette inserted by homologous recombination. (J:83226)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Itgal Mutation: 76 strains or lines available

References

• Original: J:83226 Ding ZM, et al., Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration. J Immunol. 1999 Nov 1;163(9):5029-38
• All: 73 reference(s)