Adcy3^tm1Drs
Targeted Allele Detail

Summary

• Symbol: Adcy3^tm1Drs
• Name: adenylate cyclase 3; targeted mutation 1, Daniel R Storm
• MGI ID: MGI:2661086
• Synonyms: AC3^-, AC3-M
• Gene: Adcy3 Location: Chr12:4183397-4263525 bp, + strand Genetic Position: Chr12, 1.99 cM, cytoband A-B
• Alliance: Adcy3^tm1Drs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64745
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 5' portion of exon 1 was deleted and replaced with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis. (J:64745)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adcy3 Mutation: 43 strains or lines available

References

• Original: J:64745 Wong ST, et al., Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice. Neuron. 2000 Sep;27(3):487-97
• All: 30 reference(s)