Adcy3^tm1Drs
Targeted Allele Detail

Summary

• Symbol: Adcy3^tm1Drs
• Name: adenylate cyclase 3; targeted mutation 1, Daniel R Storm
• MGI ID: MGI:2661086
• Synonyms: AC3^-, AC3-M
• Gene: Adcy3 Location: Chr12:4183397-4263525 bp, + strand Genetic Position: Chr12, 1.99 cM, cytoband A-B
• Alliance: Adcy3^tm1Drs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64745
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 5' portion of exon 1 was deleted and replaced with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis. (J:64745)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Adcy3^tm1Drs/Adcy3^tm1Drs	involves: 129X1/SvJ * C57BL/6
hm2  Disease Model	Adcy3^tm1Drs/Adcy3^tm1Drs	involves: 129X1/SvJ * C57BL/6J
ht3	Adcy3^tm1Drs/Adcy3^+	involves: 129X1/SvJ * C57BL/6
cx4	Adcy3^tm1Drs/Adcy3^tm1Drs Or10a4^tm1Mom/Or10a4^+	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
cx5	Adcy3^tm1Drs/Adcy3^tm1Drs Or8a1b^tm4Mom/Or8a1b^+	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
cx6	Adcy3^tm1Drs/Adcy3^tm1Drs Vmn1r49^tm1Mom/Vmn1r49^+	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
cx7	Adcy3^tm1Drs/Adcy3^tm1Drs Omp^tm1Mom/Omp^+	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
cx8	Adcy3^tm1Drs/Adcy3^tm1Drs Or10j5^tm2Mom/Or10j5^+	involves: 129X1/SvJ * C57BL/6

Phenotypes:

Affected Systems	hm1		hm2	ht3	cx4	cx5	cx6	cx7	cx8
show or hide all annotated terms Sex:
behavior/neurological			√
abnormal object recognition memory			√
abnormal response to new environment			√
impaired spatial learning			√
abnormal long-term spatial reference memory			√
polyphagia			√
abnormal depression-related behavior			√
behavioral despair			√
decreased grooming behavior			√
hypoactivity			√
abnormal non-rapid eye movement sleep pattern			√
increased frequency of paradoxical sleep			√
abnormal nest building behavior			√
abnormal social investigation			√
cellular		√
asthenozoospermia		√
growth/size/body	√	√
decreased body weight	√	√
obese	√	√
homeostasis/metabolism	√	√
homeostasis/metabolism phenotype	N	N
increased circulating creatinine level	√	√
decreased circulating renin level	√	√
mortality/aging	√	√
postnatal lethality, incomplete penetrance	√	√
nervous system	√	√	√		√	√	N	√	√
nervous system phenotype							N
decreased brain size			√
decreased brain weight			√
abnormal hippocampus CA1 region morphology			√
decreased dentate gyrus size			√
small hippocampus			√
decreased hippocampus volume			√
abnormal olfactory bulb morphology	√	√				√		√	√
abnormal olfactory neuron innervation pattern	√	√
abnormal dendrite arborization pattern			√
abnormal olfactory nerve morphology					√	√		√
abnormal neuron physiology			√
abnormal CNS synaptic transmission			√
abnormal excitatory postsynaptic potential			√
reduced long-term potentiation			√
renal/urinary system	√	√
renal/urinary system phenotype	N	N
decreased renal glomerular filtration rate	√	√
reproductive system	√	√
asthenozoospermia		√
impaired sperm capacitation		√
abnormal fertility/fecundity	√	√
reduced female fertility	√
decreased litter size	√	√
reduced male fertility		√
premature acrosome reaction		√
impaired fertilization	√	√
taste/olfaction	√	√	√	√
abnormal olfaction	√	√
anosmia	√	√	√
impaired olfaction				√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	hm2
major depressive disorder IDs major depressive disorder       DOID:1470 DOID:10614 DOID:2240 DOID:2241 DOID:7580 EFO:0003761 ICD10CM:F32 ICD10CM:F33.9 ICD9CM:296.2 ICD9CM:296.20 ICD9CM:296.3 ICD9CM:296.30 NCI:C34796 OMIM:608520 OMIM:608691 UMLS_CUI:C0024517 UMLS_CUI:C0154409 Close	√

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adcy3 Mutation: 43 strains or lines available

References

• Original: J:64745 Wong ST, et al., Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice. Neuron. 2000 Sep;27(3):487-97
• All: 30 reference(s)