Ezh2^tm1Tara
Targeted Allele Detail

Summary

• Symbol: Ezh2^tm1Tara
• Name: enhancer of zeste 2 polycomb repressive complex 2 subunit; targeted mutation 1, Alexander Tarakhovsky
• MGI ID: MGI:2661097
• Synonyms: Ezh2^F, Ezh2^fl
• Gene: Ezh2 Location: Chr6:47507073-47572275 bp, - strand Genetic Position: Chr6, 22.92 cM, cytoband B
• Alliance: Ezh2^tm1Tara page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83216
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Four exons encoding the SET domain were left flanked by single loxP sites after the insertion of targeting vector and subsequent in vitro excision of a floxed neo cassette. (J:83216)

Expression

In Mice Carrying this Mutation:	80 assay results 15 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ezh2 Mutation: 72 strains or lines available

References

• Original: J:83216 Su IH, et al., Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement. Nat Immunol. 2003 Feb;4(2):124-31
• All: 95 reference(s)